top of page

30-Day Get Moving Challenge

Public·16 members
Dobrynya Shiryaev
Dobrynya Shiryaev

Mayo Clinic Gastroenterology And Hepatology Boa...



Barbara Jung, MD, AGAF, is a professor and chair of medicine at the University of Washington in Seattle. As a practicing gastroenterologist and physician-scientist, her expertise in gastrointestinal disease is extensive, and her research interests range from basic to clinical science. She completed her medical degree with thesis at the Ludwig-Maximilians University in Munich, Germany. She then moved to the U. S. and completed post-doctoral studies in colon cancer at the Sidney Kimmel Cancer Center in San Diego, California under the mentorship of Dr. Michael McClelland. She completed both her internal medicine residency and gastroenterology fellowship at the University of California in San Diego in 2004 under the mentorship of Dr. John Carethers.




Mayo Clinic Gastroenterology and Hepatology Boa...



Andrew T. Chan, MD, MPH, AGAF received his ScB from Brown University, medical degree from Harvard Medical School, and master of public health from the Harvard T. H. Chan School of Public Health (HSPH). He did his internal medicine residency and chief residency, followed by gastroenterology fellowship at Massachusetts General Hospital (MGH), where he remains on faculty. He is professor of medicine at HMS, professor of immunology and infectious diseases at HSPH, chief of the clinical and translational epidemiology unit at MGH and the director of epidemiology at the MGH Cancer Center. He is the former program director of the MGH GI Fellowship Program. Dr. Chan is a gastroenterologist and a leading investigator in cancer prevention, supported as an Outstanding Investigator of the National Cancer Institute, Team Leader for the Stand Up to Cancer Gastric Cancer Interception Team, and by grants from the National Institute for Diabetes and Digestive and Kidney Diseases and the National Institute on Aging.


Michael Weinstein, MD, AGAF, began his career in private practice gastroenterology in 1985. He led the development of one the first ambulatory endoscopy centers to receive Medicare certification in 1986. His interest in the early addition of technology into medical practice includes adoption of video endoscopy in 1989, development of endowriter software with cMore (ProVation) and gMed, and as a former AMA CPT Advisory Panel representative, aided Given Imaging, Medtronics and Ethicon in requesting new CPT codes for technology innovations. In 2009, he spearheaded the merger of seven practices to form Capital Digestive Care and is now president and CEO of a practice of 69 physicians in the Washington, D.C., and suburban Mid-Atlantic region. He has a special interest in independent physician advocacy and is the immediate past president of the Digestive Health Physician Association and the clinical counselor on the AGA Governing Board.


Dr. Camilleri participates in educational and mentorship activities at Mayo Clinic and has mentored more than 80 national and international postdoctoral fellows and scientists. He maintains an active clinical practice in gastroenterology at Mayo Clinic, specializing in gastrointestinal motility disorders, gastroparesis and functional GI disorders.


He has received numerous awards and honors, including the 2012 Ismar Boas Medal from the German Society of Digestive and Metabolic Disease, the 2012 American Gastroenterological Association (AGA) Distinguished Mentor Award, the Janssen Research Award, the AGA Joseph B. Kirsner Award, the AGA Julius Friedenwald Medal in 2021, as well as honorary doctorates from the University of Antwerp (Belgium) and the University of Malta, and he was elected to the membership of the prestigious Association of American Physicians. Dr. Camilleri participates in educational and mentorship activities at Mayo Clinic and has mentored more than 80 national and international postdoctoral fellows and scientists. He maintains an active clinical practice in gastroenterology at Mayo Clinic, specializing in gastrointestinal motility disorders, gastroparesis, and functional GI disorders. He is past-president of the American Neurogastroenterology and Motility Society and the American Gastroenterological Association, former editor of Clinical Gastroenterology and Hepatology and Neurogastroenterology and Motility, and a former associate editor of American Journal of Physiology.


[1] Steinberg, M.H. (2008) Sickle Cell Anemia, the First Molecular Disease: Overview of Molecular Etiology, Pathophysiology, and Therapeutic Approaches. The Scientific World Journal, 8, 1295-1324. doi.org/10.1100/tsw.2008.157 [2] Steinberg, M.H. (2005) Predicting Clinical Severity in Sickle Cell Anaemia. British journal of haematology, 129, 465-481. doi.org/10.1111/j.1365-2141.2005.05411.x [3] Lanaro, C., Franco-Penteado, C.F., Albuqueque, D.M., Saad, S.T., Conran, N. and Costa, F.F. (2009) Altered Levels of Cytokines and Inflammatory Mediators in Plasma and Leukocytes of Sickle Cell Anemia Patients and Effects of Hydroxyurea Therapy. Journal of leukocyte biology, 85, 235-242. doi.org/10.1189/jlb.0708445 [4] Bender, M.A. and Hobbs, W. Sickle Cell Disease. In: Pagon RA, Bird TD, Dolan CR, Stephens K, Adam MP, editors. Genereviews. Seattle (WA)1993. [5] Morris, C.R. (2011) Vascular Risk Assessment in Patients with Sickle Cell Disease. Haematologica, 96, 1-5. doi.org/10.3324/haematol.2010.035097 [6] Medina-Urrutia, A., Juarez-Rojas, J.G., Cardoso-Saldana, G., Jorge-Galarza, E., Posadas-Sanchez, R., Martinez-Alvarado, R., Caracas-Portilla, N., Mendoza Perez, E. and Posadas-Romero, C. (2011) Abnormal High-Density Lipoproteins in Overweight Adolescents with Atherogenic Dyslipidemia. Pediatrics, 127, e1521-1527. [7] Elkind, M.S. (2006) Inflammation, Atherosclerosis, and Stroke. The neurologist, 12, 140-148. doi.org/10.1097/01.nrl.0000215789.70804.b0 [8] Thanoon, I.A., Abdul-Jabbar, H.A. and Taha, D.A. (2012) Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke): The Role of Ginkgo Biloba Extract. Sultan Qaboos University medical journal, 12, 197-205. [9] Milton, J.N., Sebastiani, P., Solovieff, N., Hartley, S.W., Bhatnagar, P., Arking, D.E., Dworkis, D.A., Casella, J.F., Barron-Casella, E., Bean, C.J., Hooper, W.C., DeBaun, M.R., Garrett, M.E., Soldano, K., Telen, M.J., Ashley-Koch, A., Gladwin, M.T., Baldwin, C.T., Steinberg, M.H. and Klings, E.S. (2012) A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia. PloS one, 7, e34741. doi.org/10.1371/journal.pone.0034741 [10] Ebert, E.C., Nagar, M. and Hagspiel, K.D. (2010) Gastrointestinal and Hepatic Complications of Sickle Cell Disease. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association, 8, 483-489; quiz e470. [11] Wakugawa, Y., Kiyohara, Y., Tanizaki, Y., Kubo, M., Ninomiya, T., Hata, J., Doi, Y., Okubo, K., Oishi, Y., Shikata, K., Yonemoto, K., Maebuchi, D., Ibayashi, S. and Iida, M. (2006) C-Reactive Protein and Risk of First-Ever Ischemic and Hemorrhagic Stroke in a General Japanese Population: The Hisayama Study. Stroke; a journal of cerebral circulation, 37, 27-32. doi.org/10.1161/01.STR.0000194958.88216.87 [12] Voskaridou, E., Christoulas, D. and Terpos, E. (2012) Sickle-Cell Disease and the Heart: Review of the Current Literature. British journal of haematology, 157, 664-673. [13] Costa, R.N., Conran, N., Albuquerque, D.M., Soares, P.H., Saad, S.T. and Costa, F.F. (2005) Association of the G-463a Myeloperoxidase Polymorphism with Infection in Sickle Cell Anemia. Haematologica, 90, 977-979. [14] Liu, C., Xie, G., Huang, W., Yang, Y., Li, P. and Tu, Z. (2012) Elevated Serum Myeloperoxidase Activities Are Significantly Associated with the Prevalence of Acs and High Ldl-C Levels in Chd Patients. Journal of atherosclerosis and thrombosis, 19, 435-443. doi.org/10.1111/j.1365-2141.2012.09143.x [15] Seixas, M.O., Rocha, L.C., Carvalho, M.B., Menezes, J.F., Lyra, I.M., Nascimento, V.M., Couto, R.D., Atta, A.M., Reis, M.G. and Goncalves, M.S. (2010) Levels of High-Density Lipoprotein Cholesterol (Hdl-C) among Children with Steady-State Sickle Cell Disease. Lipids in health and disease, 9, 91. doi.org/10.1186/1476-511X-9-91 [16] Wood, K.C., Hsu, L.L. and Gladwin, M.T. (2008) Sickle Cell Disease Vasculopathy: A State of Nitric Oxide Resistance. Free radical biology & medicine, 44, 1506-1528. doi.org/10.1016/j.freeradbiomed.2008.01.008 [17] Reiter, C.D., Wang, X., Tanus-Santos, J.E., Hogg, N., Cannon, R.O., 3rd, Schechter, A.N. and Gladwin, M.T. (2002) Cell-Free Hemoglobin Limits Nitric Oxide Bioavailability in Sickle-Cell Disease. Nature medicine, 8, 1383-1389. doi.org/10.1038/nm1202-799 [18] Ryter, S.W. and Tyrrell, R.M. (2000) The Heme Synthesis and Degradation Pathways: Role in Oxidant Sensitivity. Heme Oxygenase Has Both Pro- and Antioxidant Properties. Free radical biology & medicine, 28, 289-309. doi.org/10.1016/S0891-5849(99)00223-3 [19] Akinsheye, I. and Klings, E.S. (2010) Sickle Cell Anemia and Vascular Dysfunction: The Nitric Oxide Connection. Journal of cellular physiology, 224, 620-625. doi.org/10.1002/jcp.22195 [20] Villagra, J., Shiva, S., Hunter, L.A., Machado, R.F., Gladwin, M.T. and Kato, G.J. (2007) Platelet Activation in Patients with Sickle Disease, Hemolysis-Associated Pulmonary Hypertension, and Nitric Oxide Scavenging by Cell-Free Hemoglobin. Blood, 110, 2166-2172. doi.org/10.1182/blood-2006-12-061697 [21] Spiecker, M., Darius, H., Kaboth, K., Hubner, F. and Liao, J.K. (1998) Differential Regulation of Endothelial Cell Adhesion Molecule Expression by Nitric Oxide Donors and Antioxidants. Journal of leukocyte biology, 63, 732-739. [22] Aslan, M., Ryan, T.M., Adler, B., Townes, T.M., Parks, D.A., Thompson, J.A., Tousson, A., Gladwin, M.T., Patel, R.P., Tarpey, M.M., Batinic-Haberle, I., White, C.R. and Freeman, B.A. (2001) Oxygen Radical Inhibition of Nitric Oxide-Dependent Vascular Function in Sickle Cell Disease. Proceedings of the National Academy of Sciences of the United States of America, 98, 15215-15220. doi.org/10.1073/pnas.221292098 [23] Solovey, A., Kollander, R., Milbauer, L.C., Abdulla, F., Chen, Y., Kelm, R.J., Jr. and Hebbel, R.P. (2010) Endothelial Nitric Oxide Synthase and Nitric Oxide Regulate Endothelial Tissue Factor Expression in Vivo in the Sickle Transgenic Mouse. American journal of hematology, 85, 41-45. [24] Jain, S. and Gladwin, M.T. (2010) Arginine Metabolism and Nitric Oxide Bioavailability in Sickle Cell Disease. Journal of pediatric hematology/oncology, 32, e247-248. doi.org/10.1097/MPH.0b013e3181ec0b00 [25] Zhou, Z., Behymer, M. and Guchhait, P. (2011) Role of Extracellular Hemoglobin in Thrombosis and Vascular Occlusion in Patients with Sickle Cell Anemia. Anemia, 2011, 918916. doi.org/10.1155/2011/918916 [26] Morris, C.R., Kato, G.J., Poljakovic, M., Wang, X., Blackwelder, W.C., Sachdev, V., Hazen, S.L., Vichinsky, E.P., Morris, S.M., Jr. and Gladwin, M.T. (2005) Dysregulated Arginine Metabolism, Hemolysis-Associated Pulmonary Hypertension, and Mortality in Sickle Cell Disease. JAMA: the journal of the American Medical Association, 294, 81-90. doi.org/10.1001/jama.294.1.81 [27] Vilas-Boas, W., Cerqueira, B.A., Zanette, A.M., Reis, M.G., Barral-Netto, M. and Goncalves, M.S. (2010) Arginase Levels and Their Association with Th17-Related Cytokines, Soluble Adhesion Molecules (Sicam-1 and Svcam-1) and Hemolysis Markers among Steady-State Sickle Cell Anemia Patients. Annals of hematology, 89, 877-882. doi.org/10.1007/s00277-010-0954-9 [28] Bialecka, M., Robowski, P., Honczarenko, K., Roszmann, A. and Slawek, J. (2009) Genetic and Environmental Factors for Hyperhomocysteinaemia and Its Clinical Implications in Parkinson's Disease. Neurologia i neurochirurgia polska, 43, 272-285. [29] Refsum, H., Ueland, P.M., Nygard, O. and Vollset, S.E. (1998) Homocysteine and Cardiovascular Disease. Annual review of medicine, 49, 31-62. doi.org/10.1146/annurev.med.49.1.31 [30] Clarke, R., Daly, L., Robinson, K., Naughten, E., Cahalane, S., Fowler, B. and Graham, I. (1991) Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease. The New England journal of medicine, 324, 1149-1155. doi.org/10.1056/NEJM199104253241701 [31] Lowenthal, E.A., Mayo, M.S., Cornwell, P.E. and Thornley-Brown, D. (2000) Homocysteine Elevation in Sickle Cell Disease. Journal of the American College of Nutrition, 19, 608-612. [32] Siniscalchi, A., Mancuso, F., Gallelli, L., Ferreri Ibbadu, G., Biagio Mercuri, N. and De Sarro, G. (2005) Increase in Plasma Homocysteine Levels Induced by Drug Treatments in Neurologic Patients. Pharmacological research: the official journal of the Italian Pharmacological Society, 52, 367-375. [33] Dudman, N.P., Temple, S.E., Guo, X.W., Fu, W. and Perry, M.A. (1999) Homocysteine Enhances Neutrophil-Endothelial Interactions in Both Cultured Human Cells and Rats in Vivo. Circulation research, 84, 409-416. doi.org/10.1161/01.RES.84.4.409 [34] Chies, J.A. and Nardi, N.B. (2001) Sickle Cell Disease: A Chronic Inflammatory Condition. Medical hypotheses, 57, 46-50. doi.org/10.1054/mehy.2000.1310 [35] Wallace, K.L. and Linden, J. (2010) Adenosine A2a Receptors Induced on Inkt and Nk Cells Reduce Pulmonary Inflammation and Injury in Mice with Sickle Cell Disease. Blood, 116, 5010-5020. doi.org/10.1182/blood-2010-06-290643 [36] Park, S.W., Kim, M., Brown, K.M., D'Agati, V.D. and Lee, H.T. (2011) Paneth Cell-Derived Interleukin-17a Causes Multiorgan Dysfunction after Hepatic Ischemia and Reperfusion Injury. Hepatology, 53, 1662-1675. doi.org/10.1002/hep.24253 [37] Chen, G.Y. and Nunez, G. (2010) Sterile Inflammation: Sensing and Reacting to Damage. Nature reviews. Immunology, 10, 826-837. doi.org/10.1038/nri2873 [38] Akira, S., Uematsu, S. and Takeuchi, O. (2006) Pathogen Recognition and Innate Immunity. Cell, 124, 783-801. doi.org/10.1016/j.cell.2006.02.015 [39] Iwasaki, A. and Medzhitov, R. (2004) Toll-Like Receptor Control of the Adaptive Immune Responses. Nature immunology, 5, 987-995. doi.org/10.1038/ni1112 [40] Pulendran, B. (2005) Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors. Journal of immunology, 174, 2457-2465. [41] Ferwerda, B., McCall, M.B., Alonso, S., Giamarellos-Bourboulis, E.J., Mouktaroudi, M., Izagirre, N., Syafruddin, D., Kibiki, G., Cristea, T., Hijmans, A., Hamann, L., Israel, S., ElGhazali, G., Troye-Blomberg, M., Kumpf, O., Maiga, B., Dolo, A., Doumbo, O., Hermsen, C.C., Stalenhoef, A.F., van Crevel, R., Brunner, H.G., Oh, D.Y., Schumann, R.R., de la Rua, C., Sauerwein, R., Kullberg, B.J., van der Ven, A.J., van der Meer, J.W. and Netea, M.G. (2007) Tlr4 Polymorphisms, Infectious Diseases, and Evolutionary [42] Gregory, S., Zilber, M., Charron, D. and Gelin, C. (2000) Human Cd1a Molecule Expressed on Monocytes Plays an Accessory Role in the Superantigen-Induced Activation of T Lymphocytes. Human immunology, 61, 193-201. doi.org/10.1016/S0198-8859(99)00129-9 [43] Sloma, I., Zilber, M.T., Charron, D., Girot, R., Tamouza, R. and Gelin, C. (2004) Upregulation and Atypical Expression of the Cd1 Molecules on Monocytes in Sickle Cell Disease. Human immunology, 65, 1370-1376. doi.org/10.1016/j.humimm.2004.09.009 [44] Urban, B.C., Shafi, M.J., Cordery, D.V., Macharia, A., Lowe, B., Marsh, K. and Williams, T.N. (2006) Frequencies of Peripheral Blood Myeloid Cells in Healthy Kenyan Children with Alpha+ Thalassemia and the Sickle Cell Trait. The American journal of tropical medicine and hygiene, 74, 578-584 [45] Krishnegowda, G., Hajjar, A.M., Zhu, J., Douglass, E.J., Uematsu, S., Akira, S., Woods, A.S. and Gowda, D.C. (2005) Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols of Plasmodium Falciparum: Cell Signaling Receptors, Glycosylphosphatidylinositol (Gpi) Structural Requirement, and Regulation of Gpi Activity. The Journal of biological chemistry, 280, 8606-8616. doi.org/10.1074/jbc.M413541200 [46] Pichyangkul, S., Yongvanitchit, K., Kum-arb, U., Hemmi, H., Akira, S., Krieg, A.M., Heppner, D.G., Stewart, V.A., Hasegawa, H., Looareesuwan, S., Shanks, G.D. and Miller, R.S. (2004) Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway. Journal of immunology, 172, 4926-4933. [47] Lorenz, E., Mira, J.P., Frees, K.L. and Schwartz, D.A. (2002) Relevance of Mutations in the Tlr4 Receptor in Patients with Gram-Negative Septic Shock. Archives of internal medicine, 162, 1028-1032. doi.org/10.1001/archinte.162.9.1028 [48] Khansari, N., Shakiba, Y. and Mahmoudi, M. (2009) Chronic Inflammation and Oxidative Stress as a Major Cause of Age-Related Diseases and Cancer. Recent patents on inflammation & allergy drug discovery, 3, 73-80. doi.org/10.2174/187221309787158371 [49] Valdivia, P.A., Zenteno-Savin, T., Gardner, S.C. and Aguirre, A.A. (2007) Basic Oxidative Stress Metabolites in Eastern Pacific Green Turtles (Chelonia Mydas Agassizii). Comparative biochemistry and physiology. Toxicology & pharmacology: CBP, 146, 111-117. [50] Inoue, M., Sato, E.F., Nishikawa, M., Park, A.M., Kira, Y., Imada, I. and Utsumi, K. (2003) Mitochondrial Generation of Reactive Oxygen Species and Its Role in Aerobic Life. Current medicinal chemistry, 10, 2495-2505. doi.org/10.2174/0929867033456477 [51] Akopova, O.V., Kolchinskaya, L.I., Nosar, V.I., Bouryi, V.A., Mankovska, I.N. and Sagach, V.F. (2012) Cytochrome C as an Amplifier of Ros Release in Mitochondria. Fiziolohichnyi zhurnal, 58, 3-12. [52] Gutteridge, J.M., Rowley, D.A. and Halliwell, B. (1982) Superoxide-Dependent Formation of Hydroxyl Radicals and Lipid Peroxidation in the Presence of Iron Salts. Detection of 'Catalytic' Iron and Anti-Oxidant Activity in Extracellular Fluids. The Biochemical journal, 206, 605-609. [53] Wickens, A.P. (2001) Ageing and the Free Radical Theory. Respiration physiology, 128, 379-391. doi.org/10.1016/S0034-5687(01)00313-9 [54] Conner, E.M. and Grisham, M.B. (1996) Inflammation, Free Radicals, and Antioxidants. Nutrition, 12, 274-277. doi.org/10.1016/S0899-9007(96)00000-8 [55] Mateos, R. and Bravo, L. (2007) Chromatographic and Electrophoretic Methods for the Analysis of Biomarkers of Oxidative Damage to Macromolecules (DNA, Lipids, and Proteins). Journal of separation science, 30, 175-191. doi.org/10.1002/jssc.200600314 [56] Pastore, A., Federici, G., Bertini, E. and Piemonte, F. (2003) Analysis of Glutathione: Implication in Redox and Detoxification. Clinica chimica acta; international journal of clinical chemistry, 333, 19-39. [57] Esposito, K., Ciotola, M., Schisano, B., Misso, L., Giannetti, G., Ceriello, A. and Giugliano, D. (2006) Oxidative Stress in the Metabolic Syndrome. Journal of endocrinological investigation, 29, 791-795. [58] Peterhans, E. (1997) Reactive Oxygen Species and Nitric Oxide in Viral Diseases. Biological trace element research, 56, 107-116. doi.org/10.1007/BF02778986 [59] Stehbens, W.E. (2003) Oxidative Stress, Toxic Hepatitis, and Antioxidants with Particular Emphasis on Zinc. Experimental and molecular pathology, 75, 265-276. doi.org/10.1016/S0014-4800(03)00097-2 [60] Emmendoerffer, A., Hecht, M., Boeker, T., Mueller, M. and Heinrich, U. (2000) Role of Inflammation in Chemical-Induced Lung Cancer. Toxicology letters, 112-113, 185-191. doi.org/10.1016/S0378-4274(99)00285-4 [61] Segal, A.W. (2006) How Superoxide Production by Neutrophil Leukocytes Kills Microbes. Novartis Foundation symposium, 279, 92-98; discussion 98-100, 216-109. [62] Costa, A.D. and Garlid, K.D. (2008) Intramitochondrial Signaling: Interactions among Mitokatp, Pkcepsilon, Ros, and Mpt. American journal of physiology. Heart and circulatory physiology, 295, H874-882. doi.org/10.1152/ajpheart.01189.2007 [63] Fialkow, L., Wang, Y. and Downey, G.P. (2007) Reactive Oxygen and Nitrogen Species as Signaling Molecules Regulating Neutrophil Function. Free radical biology & medicine, 42, 153-164. doi.org/10.1016/j.freeradbiomed.2006.09.030 [64]


About

Welcome to the group! You can connect with other members, ge...

Members

  • LifeAtSHP
  • Shravani Chormale
    Shravani Chormale
  • Josie Allison
    Josie Allison
  • William Ong
    William Ong
  • Airam Rojas Zerpa
    Airam Rojas Zerpa
bottom of page